Lupus is an autoimmune disorder in which the immune system of our body attacks our organs and tissues. Lupus can affect many systems of the body like joints, blood cells, skin, brain, kidneys, lungs, brain, heart, etc and the first signs of lupus can be joint pain, changes in weight, and fever. The root cause of this disorder is not found yet. Many health experts and scientists believe that lupus occurs due to a combination of factors, both inside and outside the body. Some of these factors are genetics, environment, and hormones, and to have the best lupus cure, you need to fix all these factors. Let us now look into the details.
The scientific world has identified more than fifty genes that are linked to lupus. These genes are mostly found in people with a history of lupus. Most of these genes do not directly cause lupus but are believed to contribute to the risk of the disease. Lupus can also develop in people without any family history of the same. However, there are chances of other autoimmune disorders in some members of the family. Moreover, the chances of developing lupus are more in some of the ethnic groups and this can be associated with some of the genes that these people have in common.
Most of the researchers believe that environmental agents like a chemical or a virus encountered by people who are genetically susceptible to the disease trigger lupus. Scientists have not yet identified any specific environmental agents that can trigger lupus, however, the hypothesis remains likely. Even though the environmental factors that can trigger lupus are not yet identified completely, ultraviolet rays, exposure to silica, and infections are believed to trigger the same in susceptible individuals.
Hormones regulate several bodily functions. They work well as messengers of our bodies. As ninety percent of the occurrence of lupus is in females, scientists have looked at the relation between lupus and estrogen hormone. Even though both men and women produce this hormone, the production is very high in females. Many women show lupus symptoms before the start of menstruation and during pregnancy. The production of estrogen will be high at both these times. However, no causal effect has been established between estrogen and lupus. Moreover, studies conducted on women with lupus who are taking estrogen as postmenopausal therapy or as birth control pills have not shown any increase in the activity of the disease.