What Effects Do Genetics Have On Lupus?

Lupus Nephritis
Lupus Nephritis
Is Lupus Genetic
Is Lupus Genetic

Many people often ask this question: Is lupus genetic? While the precise cause of it is not known, genes appear to play a part in it. Scientists who study lupus genetics have learned much regarding the condition, who develops it, and for what reasons. Anyhow, a lot more should be learned even now. Some of the lupus-related things that researchers trying to determine are as follows.

  • To what extent it runs in families
  • Why the chance of some ethnic groups to develop lupus is four times more than that of white people
  • Whether genetics can predict which types of people are susceptible to it and, if those features can, prevent it

Genes And Lupus

Researchers have singled out over 60 genes they feel impact an individual’s possibility of developing this condition. Studies have demonstrated that histocompatibility complex genes are associated with lupus. Two of the functions of histocompatibility complex genes are building our immune response to some infectious agents, plus making a protein that copes with inflammation.

Many other genes working with histocompatibility complex genes, plus the human immune response also play a part in lupus. Those genes offer instructions to human cells to create proteins that cope with the following.

  • Signal delivery to the human immune system
  • Impairing cell receptor function in that system
  • Formulation of T-cells and B-cells, plus some antibodies
  • Creation of some autoantibodies, which include anti-La and anti-Ro
  • Secretion of cytokines

Monogenic Lupus

Experts feel that polygenic changes cause almost all cases of SLE, except for some monogenic mutation-related cases. Numerous genes may lead to lupus, but the most prevalent monogenic mutation is known as a complement deficiency.

Complement proteins are part of the clean-up process that follows an immune system attack. The said deficiency causes the process to be improper, leaving behind molecule networks that can harm your tissues. The said proteins may facilitate the creation of cytokines as well.

Some other mutations may also induce monogenic lupus. Whatever the cause may be, the outcome is an attack against human body parts.


So, is lupus hereditary? Genetic mutations seem to play a big part in lupus development, but researchers feel that is only part of the story. That is a belief based on discoveries in monozygotic twins. If one of them has lupus, then around 60% is the chance of the other twin developing it. The chance would be more in the event it was truly genetic. Over 40% of monozygotic twins do not develop this condition even when their twins do, so epigenetics may also be at play in its development.