People use ginger as a culinary ingredient, plus a treatment option for health issues such as indigestion. Anyhow, it may also have antioxidant and inflammation-reducing effects. Researchers from the Anne Arbor-based Michigan Medicine investigated whether it might aid in reducing lupus symptoms. They specifically looked into 6-gingerol, ginger’s main bioactive component.
The findings of the researchers are featured in the JCI Insight journal. In systemic lupus erythematosus (SLE), the human immune system attacks the body, so inflammation can permanently damage our tissues. Neutrophils play an important part in that inflammatory response. For your information, ‘neutrophils’ is the scientific name for white blood cells.
The study authors aimed to discover how much ginger derivatives might work in the form of aberrant neutrophil hyperactivity’s suppressor. Read on to know more about this piece of research.
The researchers looked at 6-gingerol’s effects on lupus-affected mice as part of their investigation.
They also made antiphospholipid syndrome-affected mice part of it. For your information, APS is a health condition that causes blood to clot in the vessels, and it tends to be associated with SLE.
The scientists discovered that it kept neutrophil extracellular traps’ release from happening in those two mice groups. As for the lead author of this study Ramadan Ali, NTEs originate from neutrophils. Those structures similar to spiderwebs occur due to the interaction of autoantibodies with the receptors situated on the surface of the blood cells.
NTEs cause lupus to develop as well as improve blood clot formation. Besides lessening NTEs, the above-mentioned ginger component also caused less formation of the clot.
It also appeared that 6-gingerol inhibits neutrophil enzymes known as phosphodiesterases. That inhibition caused neutrophil activation to decline.
On the whole, the study findings indicate the inflammation-reducing activity of the ginger’s compound affects the said antibodies associated with APS and lupus.
Importantly, the antibody count came down, which suggests that 6-gingerol may break the inflammation cycle and work in the form of a treatment option.
Vital Implications Of This Study
The preclinical study lays a foundation that might excite those researchers. If it is possible for them to replicate those results in human beings, it would make people more likely to use ginger supplements for blood clotting or the signs of lupus.
For some of those researchers, the study was unexpectedly enlightening. Rheumatologist and study author Jason Knight conceded that he was not aware of a lot regarding supplements.